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| 카탈로그 번호 | HY262013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, WB | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1520 | ||||
| 타겟 | IL3, Hematopoietic growth factor, Multipotential colony-stimulating factor, IL-3, Mast cell growth factor, Interleukin-3, P-cell-stimulating factor, MCGF | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P08700 | ||||
| RRID | Anti-Human IL3 Antibody (SAA1520) (abinScience Cat# HY262013, RRID:AB_3727281) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Interleukin-3 (IL3) is a ~17 kDa protein. Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. 1. Guba, SC. et al. (1989) The Journal of clinical investigation 84, 1701-6. PMID: 2556442 2. Okayama, Y. et al. (1993) Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 23, 901-10. PMID: 10779277 3. Hong, L. et al. (2020) Cytokine 136, 155268. PMID: 32889153 4. Luo, XJ. et al. (2012) PloS one 7, e50375. PMID: 23226269 5. Khapli, SM. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 171, 142-51. PMID: 12816992 6. Broughton, SE. et al. (2018) Nature communications 9, 386. PMID: 29374162 7. López, C. et al. (2017) Journal of cellular biochemistry 118, 1330-1340. PMID: 27862234 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human IL3 Antibody (SAA1520)
Detects recombinant human IL3 (Catalog No: HY262012) in indirect ELISA.
Detects recombinant human IL3 (Catalog No: HY262011) in indirect ELISA.
Western blot analysis was performed using anti-IL3 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL3 (Catalog No: HY262011)
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