Anti-Human INPPL1 Polyclonal Antibody (HD553014)

Name: Anti-Human INPPL1 Polyclonal Antibody
Brand: abinScience
SKU: HD553014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HD553014

설명

Anti-Human INPPL1 Polyclonal Antibody (HD553014) is a rabbit polyclonal antibody detecting INPPL1. Suitable for Human, Rat, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human INPPL1 (Asp422-Thr730).

타겟

EC:3.1.3.86, INPPL-1, INPPL1, Inositol polyphosphate phosphatase-like protein 1, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, Protein 51C, SH2 domain-containing inositol 5'-phosphatase 2, SH2 domain-containing inositol phosphatase 2, SHIP-2, SHIP2

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O15357

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) is a ~138 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Required for correct mitotic spindle orientation and therefore progression of mitosis. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity.

1. Vandeput, F. et al. (2006) Cellular signalling 18, 2193-9. PMID: 16824732

2. Habib, T. et al. (1998) The Journal of biological chemistry 273, 18605-9. PMID: 9660833

3. Dyson, JM. et al. (2001) The Journal of cell biology 155, 1065-79. PMID: 11739414

4. Dyson, JM. et al. (2003) Blood 102, 940-8. PMID: 12676785

5. Prasad, NK. et al. (2005) The Journal of biological chemistry 280, 13129-36. PMID: 15668240

6. Hasegawa, J. et al. (2011) The Journal of cell biology 193, 901-16. PMID: 21624956

7. Prasad, N. et al. (2002) Journal of cell science 115, 3807-15. PMID: 12235291

8. Koch, A. et al. (2005) Oncogene 24, 3436-47. PMID: 15735664

9. Zhuang, G. et al. (2007) The Journal of biological chemistry 282, 2683-94. PMID: 17135240

10. Pengal, RA. et al. (2003) The Journal of biological chemistry 278, 22657-63. PMID: 12690104

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human INPPL1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human INPPL1 Polyclonal Antibody (HD553014)

개요

이미지

참고 문헌

데이터시트

SDS