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| 카탈로그 번호 | HD628014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human IRGQ Polyclonal Antibody (HD628014) is a rabbit polyclonal antibody detecting IRGQ. Suitable for Human.
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human IRGQ (Met1-Thr331). | ||||||||
| 타겟 | IRGQ, IRGQ1, Immunity-related GTPase family Q protein | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q8WZA9 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Immunity-related GTPase family Q protein (IRGQ) is a ~62 kDa protein. Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation. Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation. Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response. In contrast to other members of the family, does not show GTPase activity. 1. Herhaus, L. et al. (2024) Cell 187, 7285-7302.e29. PMID: 39481378 | ||||||||
| 참고사항 | For research use only |
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