

| 카탈로그 번호 | HA939014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human JADE1 Polyclonal Antibody (HA939014) is a rabbit polyclonal antibody detecting JADE1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human JADE1 (Gly217-Ser363). | ||||||||
| 타겟 | KIAA1807, Jade family PHD finger protein 1, JADE1, PHD finger protein 17, Protein Jade-1, PHF17 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q6IE81 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Protein Jade-1 (JADE1) is a ~95 kDa protein. Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. 1. Doyon, Y. et al. (2006) Molecular cell 21, 51-64. PMID: 16387653 2. Saksouk, N. et al. (2009) Molecular cell 33, 257-65. PMID: 19187766 3. Miotto, B. et al. (2010) Molecular cell 37, 57-66. PMID: 20129055 4. Lalonde, ME. et al. (2013) Genes & development 27, 2009-24. PMID: 24065767 5. Panchenko, MV. et al. (2004) The Journal of biological chemistry 279, 56032-41. PMID: 15502158 6. Zhou, MI. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 11035-40. PMID: 16046545 7. Borgal, L. et al. (2012) The Journal of biological chemistry 287, 25370-80. PMID: 22654112 | ||||||||
| 참고사항 | For research use only. |
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