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| 카탈로그 번호 | HY049014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human JMJD7 Polyclonal Antibody (HY049014) is a rabbit polyclonal antibody detecting JMJD7 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human JMJD7 (Met1-Asp316). | ||||||||
| 타겟 | Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7, 1.14.11.63, 3.4.-.-, JmjC domain-containing protein 7, Jumonji domain-containing protein 7, L-lysine (3S)-hydroxylase JMJD7, JMJD7 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P0C870 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 is a ~35 kDa protein. Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Additionally, may play a role in protein biosynthesis by modifying the translation machinery. 1. Liu, H. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E7717-E7726. PMID: 28847961 2. Markolovic, S. et al. (2018) Nature chemical biology 14, 688-695. PMID: 29915238 | ||||||||
| 참고사항 | For research use only. |
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