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| 카탈로그 번호 | HA852014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human KANK2 Polyclonal Antibody (HA852014) is a rabbit polyclonal antibody detecting KANK2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human KANK2 (Ser591-Glu851). | ||||||||
| 타겟 | Ankyrin repeat domain-containing protein 25, SRC-interacting protein, SRC-1-interacting protein, SRC1-interacting protein, ANKRD25, KIAA1518, MXRA3, KN motif and ankyrin repeat domain-containing protein 2, Matrix-remodeling-associated protein 3, KANK2, SIP | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q63ZY3 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | KN motif and ankyrin repeat domain-containing protein 2 (KANK2) is a ~91 kDa protein. Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. 1. Zhang, Y. et al. (2007) The EMBO journal 26, 2645-57. PMID: 17476305 2. Wang, D. et al. (2012) The Journal of biological chemistry 287, 12612-21. PMID: 22371500 3. Ramot, Y. et al. (2014) Journal of medical genetics 51, 388-94. PMID: 24671081 4. Zhu, Y. et al. (2008) Biochimica et biophysica acta 1780, 128-33. PMID: 17996375 5. Gee, HY. et al. (2015) The Journal of clinical investigation 125, 2375-84. PMID: 25961457 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-CDC5L polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: Mouse testis lysate
Lane 4: Rat testis lysate
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