Anti-Human KAT2B Polyclonal Antibody (HA390014)

Name: Anti-Human KAT2B Polyclonal Antibody
Brand: abinScience
SKU: HA390014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HA390014

설명

Anti-Human KAT2B Polyclonal Antibody (HA390014) is a rabbit polyclonal antibody detecting KAT2B in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human KAT2B (Leu352-Lys832).

타겟

P300/CBP-associated factor, P/CAF, Histone acetylase PCAF, Lysine acetyltransferase 2B, Spermidine acetyltransferase KAT2B, PCAF, Histone acetyltransferase KAT2B, KAT2B, Histone acetyltransferase PCAF

정제

Purified by antigen affinity column.

등록번호

Q92831

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Histone acetyltransferase KAT2B is a ~93 kDa protein. Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A.

1. Ogryzko, VV. et al. (1996) Cell 87, 953-9. PMID: 8945521

2. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905

3. Martínez-Balbás, MA. et al. (2000) The EMBO journal 19, 662-71. PMID: 10675335

4. Xia, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 16564-9. PMID: 23001180

5. Lin, R. et al. (2013) Molecular cell 51, 506-518. PMID: 23932781

6. Chen, S. et al. (2016) Nature communications 7, 10734. PMID: 26867678

7. Fournier, M. et al. (2016) Nature communications 7, 13227. PMID: 27796307

8. Ghosh, TK. et al. (2018) Journal of molecular and cellular cardiology 114, 185-198. PMID: 29174768

9. Zhang, W. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 9855-60. PMID: 9707565

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human KAT2B Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human KAT2B Polyclonal Antibody (HA390014)

개요

이미지

참고 문헌

데이터시트

SDS