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| 카탈로그 번호 | HB186014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human KCNA4 Polyclonal Antibody (HB186014) is a rabbit polyclonal antibody detecting KCNA4/Kv1.4 K+ channel in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human KCNA4 (Glu176-Gly274). | ||||||||
| 타겟 | Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, HPCN2, Voltage-gated K(+) channel HuKII, Potassium voltage-gated channel subfamily A member 4, KCNA4L, KCNA4, Voltage-gated potassium channel subunit Kv1.4 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P22459 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Potassium voltage-gated channel subfamily A member 4 (KCNA4/Kv1.4 K+ channel) is a ~73 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. 1. Ramaswami, M. et al. (1990) Molecular and cellular neurosciences 1, 214-23. PMID: 19912772 2. Po, S. et al. (1993) Circulation research 72, 1326-36. PMID: 8495559 3. Imbrici, P. et al. (2006) The European journal of neuroscience 24, 3073-83. PMID: 17156368 | ||||||||
| 참고사항 | For research use only. |
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