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| 카탈로그 번호 | HF003013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1808 | ||||
| 타겟 | EAG channel 1, KCNH1, Voltage-gated potassium channel subunit Kv10.1, h-eag, hEAG1, Ether-a-go-go potassium channel 1, EAG, EAG1, Potassium voltage-gated channel subfamily H member 1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | O95259 | ||||
| RRID | Anti-Human KCNH1/EAG1 Antibody (SAA1808) (abinScience Cat# HF003013, RRID:AB_3727570) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Voltage-gated delayed rectifier potassium channel KCNH1 (EAG1) is a ~111 kDa protein. Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve. 1. Schönherr, R. et al. (2000) The EMBO journal 19, 3263-71. PMID: 10880439 2. Schönherr, R. et al. (2002) FEBS letters 514, 204-8. PMID: 11943152 3. Marques-Carvalho, MJ. et al. (2012) Journal of molecular biology 423, 34-46. PMID: 22732247 4. Simons, C. et al. (2015) Nature genetics 47, 73-7. PMID: 25420144 5. Mortensen, LS. et al. (2015) The Journal of physiology 593, 181-96. PMID: 25556795 6. Kortüm, F. et al. (2015) Nature genetics 47, 661-7. PMID: 25915598 7. Han, B. et al. (2016) Scientific reports 6, 23417. PMID: 27005320 8. Lörinczi, E. et al. (2016) The Journal of biological chemistry 291, 17907-18. PMID: 27325704 9. Marques-Carvalho, MJ. et al. (2016) Structure (London, England : 1993) 24, 1742-1754. PMID: 27618660 10. Ma, L. et al. (2018) Biochemical pharmacology 158, 60-72. PMID: 30149017 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human KCNH1/EAG1 Antibody (SAA1808)
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