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| 카탈로그 번호 | HP303014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human KDM2A Polyclonal Antibody (HP303014) is a rabbit polyclonal antibody detecting KDM2A. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human KDM2A (Thr931-Ser1162). | ||||||||
| 타겟 | CXXC-type zinc finger protein 8, CXXC8, EC:1.14.11.27, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, FBL11, FBL7, FBXL11, JHDM1A, JmjC domain-containing histone demethylation protein 1A, KDM2A, KIAA1004, Lysine-specific demethylase 2A, [Histone-H3]-lysine-36 demethylase 1A | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9Y2K7 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Lysine-specific demethylase 2A (KDM2A) is a ~132 kDa protein. Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. 1. Reischl, S. et al. (2015) Journal of biological rhythms 30, 291-301. PMID: 26037310 | ||||||||
| 참고사항 | For research use only |
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