Anti-Human KDM7A Polyclonal Antibody (HD363014)

Name: Anti-Human KDM7A Polyclonal Antibody
Brand: abinScience
SKU: HD363014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HD363014

설명

Anti-Human KDM7A Polyclonal Antibody (HD363014) is a rabbit polyclonal antibody detecting KDM7A. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human KDM7A (Gln116-Asn479).

타겟

EC:1.14.11.65, JHDM1D, JmjC domain-containing histone demethylation protein 1D, KDM7, KDM7A, KIAA1718, Lysine-specific demethylase 7, Lysine-specific demethylase 7A, [histone H3]-dimethyl-L-lysine9 demethylase 7A

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q6ZMT4

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Lysine-specific demethylase 7A (KDM7A) is a ~106 kDa protein. Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.

1. Horton, JR. et al. (2010) Nature structural & molecular biology 17, 38-43. PMID: 20023638

2. Qi, HH. et al. (2010) Nature 466, 503-7. PMID: 20622853

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human KDM7A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human KDM7A Polyclonal Antibody (HD363014)

개요

이미지

참고 문헌

데이터시트

SDS