

| 카탈로그 번호 | HD508014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human KIDINS220 Polyclonal Antibody (HD508014) is a rabbit polyclonal antibody detecting KIDINS220. Suitable for Rat and Human.
Highlights
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| 종 반응성 | Human, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human KIDINS220 (Met1-Lys168). | ||||||||
| 타겟 | ARMS, Ankyrin repeat-rich membrane-spanning protein, KIAA1250, KIDINS220, Kinase D-interacting substrate of 220 kDa | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9ULH0 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Kinase D-interacting substrate of 220 kDa (KIDINS220) is a ~196 kDa protein. Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. | ||||||||
| 참고사항 | For research use only |
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