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| 카탈로그 번호 | HT004014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human KMT2D (Val5381-Met5536). | ||||||||
| 타겟 | KMT2D, Histone-lysine N-methyltransferase 2D, Myeloid/lymphoid or mixed-lineage leukemia protein 2, ALL1-related protein, MLL4, ALR, Lysine N-methyltransferase 2D, MLL2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O14686 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Histone-lysine N-methyltransferase 2D (KMT2D) is a ~593 kDa protein. Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. 1. Shinsky, SA. et al. (2015) The Journal of biological chemistry 290, 6361-75. PMID: 25561738 2. Cho, YW. et al. (2007) The Journal of biological chemistry 282, 20395-406. PMID: 17500065 3. Mo, R. et al. (2006) The Journal of biological chemistry 281, 15714-20. PMID: 16603732 | ||||||||
| 참고사항 | For research use only. |
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