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| 카탈로그 번호 | HP399013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, IF, IP, IP-MS | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1 | ||||
| 클론 ID | SAA0209 | ||||
| 타겟 | Lethal(3)malignant brain tumor-like protein 3, H-l(3)mbt-like protein 3, KIAA1798, L3MBTL3, L3mbt-like 3, MBT-1, L(3)mbt-like protein 3, MBT1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q96JM7 | ||||
| RRID | Anti-Human L3MBTL3 IP Antibody (SAA0209) (abinScience Cat# HP399013, RRID:AB_3729743) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) is a ~88 kDa protein. Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells. 1. Xu, T. et al. (2017) The EMBO journal 36, 3232-3249. PMID: 29030483 2. Leng, F. et al. (2018) Nature communications 9, 1641. PMID: 29691401 3. Zhang, C. et al. (2019) The Journal of biological chemistry 294, 476-489. PMID: 30442713 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human L3MBTL3 IP Antibody (SAA0209)
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