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| 카탈로그 번호 | HT273014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human LAMTOR5/HBXIP Polyclonal Antibody (HT273014) is a rabbit polyclonal antibody detecting LAMTOR5. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human LAMTOR5/HBXIP (Met1-Ser91). | ||||||||
| 타겟 | HBV X-interacting protein, HBX-interacting protein, HBXIP, Hepatitis B virus X-interacting protein, LAMTOR5, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5, Ragulator complex protein LAMTOR5, XIP | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O43504 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Ragulator complex protein LAMTOR5 (HBXIP) is a ~9 kDa protein. As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. 1. Bar-Peled, L. et al. (2012) Cell 150, 1196-208. PMID: 22980980 2. Yonehara, R. et al. (2017) Nature communications 8, 1625. PMID: 29158492 3. Shen, K. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 9545-9550. PMID: 30181260 4. de Araujo, MEG. et al. (2017) Science (New York, N.Y.) 358, 377-381. PMID: 28935770 5. Su, MY. et al. (2017) Molecular cell 68, 835-846.e3. PMID: 29107538 | ||||||||
| 참고사항 | For research use only |
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