中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HA517014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human LATS1 Polyclonal Antibody (HA517014) is a rabbit polyclonal antibody detecting LATS1 in ELISA, IHC, WB. Suitable for Mus musculus and Human.
Highlights
|
||||||||
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human LATS1 (Ser635-Tyr1076). | ||||||||
| 타겟 | LATS1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95835 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 대체 이름 | Serine/threonine-protein kinase LATS1, 2.7.11.1, Large tumor suppressor homolog 1, WARTS protein kinase, h-warts, LATS1, WARTS | ||||||||
| 배경 | Serine/threonine-protein kinase LATS1 is a ~126 kDa protein. Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. 1. Nishiyama, Y. et al. (1999) FEBS letters 459, 159-65. PMID: 10518011 2. Hirota, T. et al. (2000) The Journal of cell biology 149, 1073-86. PMID: 10831611 3. Hao, Y. et al. (2008) The Journal of biological chemistry 283, 5496-509. PMID: 18158288 4. Meng, Z. et al. (2015) Nature communications 6, 8357. PMID: 26437443 5. Britschgi, A. et al. (2017) Nature 541, 541-545. PMID: 28068668 10. Nie, L. et al. (2024) Molecular cell 84, 3336-3353.e7. PMID: 39173637 | ||||||||
| 참고사항 | For research use only. |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
