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| 카탈로그 번호 | HY018013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1559 | ||||
| 타겟 | T cell-specific protein-tyrosine kinase, LSK, LCK, Protein YT16, p56-LCK, Tyrosine-protein kinase Lck, Lymphocyte cell-specific protein-tyrosine kinase, Proto-oncogene Lck, Leukocyte C-terminal Src kinase | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P06239 | ||||
| RRID | Anti-Human LCK Antibody (SAA1559) (abinScience Cat# HY018013, RRID:AB_3727320) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Tyrosine-protein kinase Lck is a ~58 kDa protein. Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR-CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR-CD3 signaling pathway. 1. Barber, EK. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 3277-81. PMID: 2470098 2. Du, J. et al. (2025) Cell 188, 4025-4042.e20. PMID: 40592325 3. Jung, SH. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 197, 942-52. PMID: 27335501 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human LCK Antibody (SAA1559)
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