

| 카탈로그 번호 | HF870014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human LETM1 (Leu231-Thr426). | ||||||||
| 타겟 | LETM1, Leucine zipper-EF-hand-containing transmembrane protein 1, Mitochondrial proton/calcium exchanger protein | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95202 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Mitochondrial proton/calcium exchanger protein (LETM1) is a ~83 kDa protein. Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Also functions as an electroneutral mitochondrial proton/potassium exchanger. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. 1. Tamai, S. et al. (2008) Journal of cell science 121, 2588-600. PMID: 18628306 2. Jiang, D. et al. (2009) Science (New York, N.Y.) 326, 144-7. PMID: 19797662 3. Tsai, MF. et al. (2014) The Journal of general physiology 143, 67-73. PMID: 24344246 4. De Marchi, U. et al. (2014) The Journal of biological chemistry 289, 20377-85. PMID: 24898248 5. Huang, E. et al. (2017) Nature communications 8, 1399. PMID: 29123128 6. Nakamura, S. et al. (2020) Communications biology 3, 99. PMID: 32139798 7. Kaiyrzhanov, R. et al. (2022) American journal of human genetics 109, 1692-1712. PMID: 36055214 8. Austin, S. et al. (2022) EMBO reports 23, e54978. PMID: 36321428 | ||||||||
| 참고사항 | For research use only. |
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