Anti-Human LIMK2 Polyclonal Antibody (HW771014)

Name: Anti-Human LIMK2 Polyclonal Antibody
Brand: abinScience
SKU: HW771014
Price: 168 USD
Availability: InStock

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사양:

50ug
100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HW771014

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human LIMK2 (Asp330-Pro638).

타겟

LIM domain kinase 2, LIMK-2, LIMK2

정제

Purified by antigen affinity column.

등록번호

P53671

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

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제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

LIM domain kinase 2 (LIMK2) is a ~72 kDa protein. Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1.

1. Maekawa, M. et al. (1999) Science (New York, N.Y.) 285, 895-8. PMID: 10436159

2. Sumi, T. et al. (2001) The Journal of biological chemistry 276, 670-6. PMID: 11018042

3. Heng, YW. et al. (2012) Journal of cell science 125, 1579-90. PMID: 22328514

4. Okano, I. et al. (1995) The Journal of biological chemistry 270, 31321-30. PMID: 8537403

5. Kim, J. et al. (2015) Nature communications 6, 6781. PMID: 25849865

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human LIMK2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human LIMK2 Polyclonal Antibody (HW771014)

개요

이미지

참고 문헌

데이터시트

SDS

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