Anti-Human LONP1 Polyclonal Antibody (HA513014)

Name: Anti-Human LONP1 Polyclonal Antibody
Brand: abinScience
SKU: HA513014
Price: 96 USD
Availability: InStock

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개요
이미지
참고 문헌
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SDS

개요

카탈로그 번호

HA513014

설명

Anti-Human LONP1 Polyclonal Antibody (HA513014) is a rabbit polyclonal antibody detecting LONP1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Bovine, Mus musculus, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human LONP1 (Phe421-Phe947).

타겟

LONP1

정제

Purified by antigen affinity column.

등록번호

P36776

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

Lon protease homolog, mitochondrial, 3.4.21.53, LONHs, Lon protease-like protein, LONP, Mitochondrial ATP-dependent protease Lon, Serine protease 15, LONP1, PRSS15

배경

Lon protease homolog, mitochondrial (LONP1) is a ~106 kDa protein. ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome.

1. Bota, DA. et al. (2002) Nature cell biology 4, 674-80. PMID: 12198491

2. Ondrovicová, G. et al. (2005) The Journal of biological chemistry 280, 25103-10. PMID: 15870080

3. Granot, Z. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 2164-77. PMID: 17579211

4. Sekine, Y. et al. (2023) Molecular cell 83, 2059-2076.e6. PMID: 37327776

5. Wang, N. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 11247-51. PMID: 8248235

6. Kunová, N. et al. (2017) Scientific reports 7, 631. PMID: 28377575

참고사항

For research use only.

이미지

Western blot

Western blot analysis was performed using anti-LONP1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: Mouse heart lysate

참고 문헌

데이터시트

Anti-Human LONP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human LONP1 Polyclonal Antibody (HA513014)

개요

이미지

참고 문헌

데이터시트

SDS

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