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| 카탈로그 번호 | HC293013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1765 | ||||
| 타겟 | Platelet-activating factor acetylhydrolase, PAFAH, PAF 2-acylhydrolase, PAF acetylhydrolase, 2-acetyl-1-alkylglycerophosphocholine esterase, 1-alkyl-2-acetylglycerophosphocholine esterase, LDL-PLA(2), LDL-associated phospholipase A2, PLA2G7, Group-VIIA phospholipase A2, gVIIA-PLA2 | ||||
| 내독소 수준 | < 10 EU/mg | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q13093 | ||||
| RRID | Anti-Human Lp-PLA2/PLA2G7/PAF-AH Antibody (SAA1765) (abinScience Cat# HC293013, RRID:AB_3727526) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Platelet-activating factor acetylhydrolase (Lp-PLA2/PLA2G7) is a ~50 kDa protein. Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response. At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups. Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells. 1. Stafforini, DM. et al. (1999) The Journal of biological chemistry 274, 7018-24. PMID: 10066756 2. Stafforini, DM. et al. (2006) The Journal of biological chemistry 281, 4616-23. PMID: 16371369 3. Kriska, T. et al. (2007) The Journal of biological chemistry 282, 100-8. PMID: 17090529 4. Stremler, KE. et al. (1991) The Journal of biological chemistry 266, 11095-103. PMID: 2040620 5. Tjoelker, LW. et al. (1995) Nature 374, 549-53. PMID: 7700381 6. Tew, DG. et al. (1996) Arteriosclerosis, thrombosis, and vascular biology 16, 591-9. PMID: 8624782 7. Min, JH. et al. (1999) Biochemistry 38, 12935-42. PMID: 10504265 9. Gardner, AA. et al. (2008) The Journal of biological chemistry 283, 17099-106. PMID: 18434304 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human Lp-PLA2/PLA2G7/PAF-AH Antibody (SAA1765)
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