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| 카탈로그 번호 | HB966013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1618 | ||||
| 타겟 | TYK1, Leukocyte tyrosine kinase receptor, LTK, Protein tyrosine kinase 1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P29376 | ||||
| RRID | Anti-Human LTK Antibody (SAA1618) (abinScience Cat# HB966013, RRID:AB_3727379) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Leukocyte tyrosine kinase receptor (LTK) is a ~91 kDa protein. Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. 1. Honda, H. et al. (1999) Oncogene 18, 3821-30. PMID: 10445845 2. Farhan, H. et al. (2010) The Journal of cell biology 189, 997-1011. PMID: 20548102 3. Reshetnyak, AV. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 8340-8345. PMID: 30061385 4. De Munck, S. et al. (2021) Nature 600, 143-147. PMID: 34646012 5. Yamada, S. et al. (2008) Neuroreport 19, 1733-8. PMID: 18849880 6. Ueno, H. et al. (1997) Oncogene 14, 3067-72. PMID: 9223670 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human LTK Antibody (SAA1618)
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