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| 카탈로그 번호 | HA130014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human Malin Polyclonal Antibody (HA130014) is a rabbit polyclonal antibody detecting Malin. Suitable for Human.
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human Malin (Gly112-Gly395). | ||||||||
| 타겟 | E3 ubiquitin-protein ligase NHLRC1, EC:2.3.2.27, EPM2B, Malin, NHL repeat-containing protein 1, NHLRC1, RING-type E3 ubiquitin transferase NHLRC1 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q6VVB1 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | E3 ubiquitin-protein ligase NHLRC1 (Malin) is a ~42 kDa protein. E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. | ||||||||
| 참고사항 | For research use only |
Western blot analysis was performed using anti-NHLRC1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse heart lysate
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