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| 카탈로그 번호 | HW837014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human MAP2K6 Polyclonal Antibody (HW837014) is a rabbit polyclonal antibody detecting MAP2K6 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human MAP2K6 (Phe46-Pro306). | ||||||||
| 타겟 | MEK6, Dual specificity mitogen-activated protein kinase kinase 6, SAPKK-3, PRKMK6, MAPK/ERK kinase 6, Stress-activated protein kinase kinase 3, MAP2K6, SKK3, MKK6, MAPKK 6, SAPKK3, MEK 6, MAP kinase kinase 6, SAPK kinase 3 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P52564 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) is a ~37 kDa protein. Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. | ||||||||
| 참고사항 | For research use only. |
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