Anti-Human MAPDA Polyclonal Antibody (HD676014)

Name: Anti-Human MAPDA Polyclonal Antibody
Brand: abinScience
SKU: HD676014
Price: 168 USD
Availability: InStock

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사양:

50ug
100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HD676014

설명

Anti-Human MAPDA Polyclonal Antibody (HD676014) is a rabbit polyclonal antibody detecting MAPDA. Suitable for Human.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human MAPDA (Met1-Ile355).

타겟

ADAL, ADAL1, Adenosine deaminase-like protein, EC:3.5.4.-, HsMAPDA, MAPDA, N6,N6-dimethyl-AMP deaminase, N6-Methyl-AMP deaminase, N6-isopentenyl-AMP deaminase, N6-mAMP deaminase, N6-methyl-AMP aminohydrolase

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q6DHV7

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

N6-Methyl-AMP deaminase (MAPDA) is a ~40 kDa protein. Deaminase involved in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Acts downstream of ADK and catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotides N(6)-methyl-AMP (m6AMP), N(6),N(6)-dimethyl-AMP (m6,6AMP) and N(6)-isopentenyl-AMP (i6AMP) to produce inositol monophosphate (IMP). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro.

1. Ogawa, A. et al. (2025) Cell 188, 6151-6169.e24. PMID: 40840445

2. Murakami, E. et al. (2011) Journal of medicinal chemistry 54, 5902-14. PMID: 21755941

3. Chen, M. et al. (2018) The Plant cell 30, 1511-1522. PMID: 29884623

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human MAPDA Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human MAPDA Polyclonal Antibody (HD676014)

개요

이미지

참고 문헌

데이터시트

SDS