Anti-Human MARCHF8 Polyclonal Antibody (HP368014)

Name: Anti-Human MARCHF8 Polyclonal Antibody
Brand: abinScience
SKU: HP368014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HP368014

설명

Anti-Human MARCHF8 Polyclonal Antibody (HP368014) is a rabbit polyclonal antibody detecting MARCHF8 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Xenopus laevis, and Xenopus tropicalis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human MARCHF8 (Ser13-Lys137).

타겟

Cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCHF8, MARCH-VIII, MIR, RING finger protein 178, MARCHF8, Membrane-associated RING-CH protein VIII, c-MIR, MARCH8, Membrane-associated RING finger protein 8, RNF178, RING-type E3 ubiquitin transferase MARCHF8

정제

Purified by antigen affinity column.

등록번호

Q5T0T0

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

E3 ubiquitin-protein ligase MARCHF8 is a ~32 kDa protein. E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity. Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins. Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation. Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses.

1. Liu, X. et al. (2021) Nature communications 12, 4427. PMID: 34285233

2. Zhang, Y. et al. (2022) Microbiology spectrum 10, e0061821. PMID: 35019698

3. Yang, X. et al. (2022) Science signaling 15, eabk3067. PMID: 35503863

4. Lapaque, N. et al. (2009) The Journal of biological chemistry 284, 7007-16. PMID: 19117940

5. Gauvreau, ME. et al. (2009) Traffic (Copenhagen, Denmark) 10, 1518-27. PMID: 19566897

6. Yu, C. et al. (2020) mBio 11. PMID: 32934085

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human MARCHF8 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

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어세이 키트

Anti-Human MARCHF8 Polyclonal Antibody (HP368014)

개요

이미지

참고 문헌

데이터시트

SDS

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