Anti-Human MCC Polyclonal Antibody (HB931014)

Name: Anti-Human MCC Polyclonal Antibody
Brand: abinScience
SKU: HB931014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HB931014

설명

Anti-Human MCC Polyclonal Antibody (HB931014) is a rabbit polyclonal antibody detecting MCC in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human MCC (Leu224-Ser294).

타겟

MCC, Protein MCC, Colorectal mutant cancer protein

정제

Purified by antigen affinity column.

등록번호

P23508

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Colorectal mutant cancer protein (MCC) is a ~93 kDa protein. Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity.

1. Fukuyama, R. et al. (2008) Oncogene 27, 6044-55. PMID: 18591935

2. Arnaud, C. et al. (2009) FEBS letters 583, 2326-32. PMID: 19555689

3. Pangon, L. et al. (2012) Biochimica et biophysica acta 1823, 1058-67. PMID: 22480440

4. Pangon, L. et al. (2015) International journal of cancer 136, 55-64. PMID: 24824780

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human MCC Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human MCC Polyclonal Antibody (HB931014)

개요

이미지

참고 문헌

데이터시트

SDS