Anti-Human MORC3 Polyclonal Antibody (HD500014)

Name: Anti-Human MORC3 Polyclonal Antibody
Brand: abinScience
SKU: HD500014
Price: 168 USD
Availability: InStock

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100ug

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개요
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SDS

개요

카탈로그 번호

HD500014

설명

Anti-Human MORC3 Polyclonal Antibody (HD500014) is a rabbit polyclonal antibody detecting MORC3. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human MORC3 (Met1-Glu455).

타겟

KIAA0136, MORC family CW-type zinc finger protein 3, MORC3, NXP2, Nuclear matrix protein 2, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q14149

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

MORC family CW-type zinc finger protein 3 (MORC3) is a ~107 kDa protein. Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3.

1. Sloan, E. et al. (2016) Journal of virology 90, 8621-33. PMID: 27440897

2. Gaidt, MM. et al. (2021) Nature 600, 138-142. PMID: 34759314

3. Takahashi, K. et al. (2007) Molecular biology of the cell 18, 1701-9. PMID: 17332504

4. Mimura, Y. et al. (2010) Journal of cell science 123, 2014-24. PMID: 20501696

5. Kimura, Y. et al. (2002) The Journal of biological chemistry 277, 20611-7. PMID: 11927593

6. Liu, Y. et al. (2016) The Journal of biological chemistry 291, 9000-13. PMID: 26933034

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human MORC3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human MORC3 Polyclonal Antibody (HD500014)

개요

이미지

참고 문헌

데이터시트

SDS