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| 카탈로그 번호 | HP714025 |
|---|---|
| 설명 |
Anti-Human MRGPRX2/MRGX2 Monoclonal Antibody (1A452) [1A452] (HP714025) is a mouse monoclonal antibody in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, IHC, WB |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1 |
| 클론 ID | 1A452 |
| 면역원 | Recombinant Human MRGPRX2/MRGX2 Protein. |
| 타겟 | Mas-related G protein-coupled receptor member X2, MRGPRX2, MRGX2 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q96LB1 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Mas-related G-protein coupled receptor member X2, MRGX2, MRGPRX2 |
| 배경 | Mas-related G-protein coupled receptor member X2 (MRGPRX2/MRGX2) is a ~37 kDa protein. Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions. A secretagogue is an agent that promotes the secretion of hormones, neurohormones, chemical neurotransmitters or other compounds synthesized and secreted by cells. Basic secretagogues comprise a set of cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. MRGPRX2 is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i) coupling mediates inhibition of adenylate cyclase activity. 1. Subramanian, H. et al. (2011) The Journal of biological chemistry 286, 44739-49. PMID: 22069323 2. McNeil, BD. et al. (2015) Nature 519, 237-41. PMID: 25517090 3. Lansu, K. et al. (2017) Nature chemical biology 13, 529-536. PMID: 28288109 4. Cao, C. et al. (2021) Nature 600, 170-175. PMID: 34789874 5. Yang, F. et al. (2021) Nature 600, 164-169. PMID: 34789875 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human MRGPRX2/MRGX2 Monoclonal Antibody (1A452)
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