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| 카탈로그 번호 | HW733013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1, kappa | ||||
| 클론 ID | SAA2296 | ||||
| 타겟 | Serine/threonine-protein kinase mTOR, EC:2.7.11.1, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, Tyrosine-protein kinase mTOR, EC:2.7.10.2, MTOR | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P42345 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Serine/threonine-protein kinase mTOR is a ~288 kDa protein. Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). 1. Park, IH. et al. (2002) The Journal of biological chemistry 277, 31423-9. PMID: 12087098 2. Kim, DH. et al. (2002) Cell 110, 163-75. PMID: 12150925 3. Hara, K. et al. (2002) Cell 110, 177-89. PMID: 12150926 4. Choi, JH. et al. (2002) EMBO reports 3, 988-94. PMID: 12231510 5. Kim, DH. et al. (2003) Molecular cell 11, 895-904. PMID: 12718876 6. Inoki, K. et al. (2003) Cell 115, 577-90. PMID: 14651849 7. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862 8. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718 9. Brugarolas, J. et al. (2004) Genes & development 18, 2893-904. PMID: 15545625 10. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470 | ||||
| 참고사항 | For research use only |
SDS-PAGE for Anti-Human MTOR Antibody (SAA2296)
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