Anti-Human MTOR Polyclonal Antibody (HW733014)

Name: Anti-Human MTOR Polyclonal Antibody
Brand: abinScience
SKU: HW733014
Price: 168 USD
Availability: InStock

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100ug

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개요
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SDS

개요

카탈로그 번호

HW733014

설명

Anti-Human MTOR Polyclonal Antibody (HW733014) is a rabbit polyclonal antibody detecting mTOR in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human MTOR (Ser27-Gln291).

타겟

Serine/threonine-protein kinase mTOR, 2.7.11.1, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P42345, P42346, Q9JLN9

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Serine/threonine-protein kinase mTOR is a ~288 kDa protein. Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).

1. Park, IH. et al. (2002) The Journal of biological chemistry 277, 31423-9. PMID: 12087098

2. Kim, DH. et al. (2002) Cell 110, 163-75. PMID: 12150925

3. Hara, K. et al. (2002) Cell 110, 177-89. PMID: 12150926

4. Choi, JH. et al. (2002) EMBO reports 3, 988-94. PMID: 12231510

5. Kim, DH. et al. (2003) Molecular cell 11, 895-904. PMID: 12718876

6. Inoki, K. et al. (2003) Cell 115, 577-90. PMID: 14651849

7. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862

8. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718

9. Brugarolas, J. et al. (2004) Genes & development 18, 2893-904. PMID: 15545625

10. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human MTOR Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human MTOR Polyclonal Antibody (HW733014)

개요

이미지

참고 문헌

데이터시트

SDS

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