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| 카탈로그 번호 | HC674014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human NFATC2 Polyclonal Antibody (HC674014) is a rabbit polyclonal antibody detecting NFATc2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NFATC2 (Ser407-Asn565). | ||||||||
| 타겟 | NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, T-cell transcription factor NFAT1, NFATC2, NF-ATp, NFAT1, NFATP | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q13469 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2) is a ~100 kDa protein. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. Is involved in the negative regulation of chondrogenesis. Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. 1. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 2. Yiu, GK. et al. (2011) The Biochemical journal 440, 157-66. PMID: 21871017 3. Sharma, M. et al. (2022) Blood 140, 1858-1874. PMID: 35789258 | ||||||||
| 참고사항 | For research use only. |
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