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| 카탈로그 번호 | HA042014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human NINJ1 Polyclonal Antibody (HA042014) is a rabbit polyclonal antibody detecting NINJ1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NINJ1 (Asp2-Leu80 & Gln142-Gln152). | ||||||||
| 타겟 | Ninjurin-1, Nerve injury-induced protein 1, Secreted ninjurin-1, Soluble ninjurin-1, NINJ1 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q92982 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ninjurin-1 (NINJ1) is a ~16 kDa protein. Effector of various programmed cell death, such as pyroptosis and necroptosis, which mediates plasma membrane rupture (cytolysis). Oligomerizes in response to death stimuli and forms ring-like structures on the plasma membrane: acts by cutting and shedding membrane disks, like a cookie cutter, leading to membrane damage and loss that cannot be repaired by the cell. Plasma membrane rupture leads to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response. Mechanistically, mediates plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane. Induces plasma membrane rupture downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively. 1. Kayagaki, N. et al. (2021) Nature 591, 131-136. PMID: 33472215 2. Borges, JP. et al. (2022) eLife 11. PMID: 36468682 3. Kayagaki, N. et al. (2023) Nature 618, 1072-1077. PMID: 37196676 4. Degen, M. et al. (2023) Nature 618, 1065-1071. PMID: 37198476 5. David, L. et al. (2024) Cell 187, 2224-2235.e16. PMID: 38614101 6. Sahoo, B. et al. (2025) Cell 188, 292-302.e11. PMID: 39667936 | ||||||||
| 참고사항 | For research use only. |
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