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| 카탈로그 번호 | HV001013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, Neutralization | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | 18# | ||||
| 타겟 | NLRP3, NACHT, LRR and PYD domains-containing protein 3, Caterpiller protein 1.1, C1orf7, PYPAF1, PYRIN-containing APAF1-like protein 1, CIAS1, CLR1.1, Cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, Angiotensin/vasopressin receptor AII/AVP-like, NALP3 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q96P20 | ||||
| RRID | Anti-Human NLRP3 Antibody (18#) (abinScience Cat# HV001013, RRID:AB_3727187) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | NACHT, LRR and PYD domains-containing protein 3 (NLRP3) is a ~118 kDa protein. Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis. In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC. Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis. Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses. Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. 1. Martinon, F. et al. (2006) Nature 440, 237-41. PMID: 16407889 2. Dostert, C. et al. (2008) Science (New York, N.Y.) 320, 674-7. PMID: 18403674 3. Hornung, V. et al. (2008) Nature immunology 9, 847-56. PMID: 18604214 4. Subramanian, N. et al. (2013) Cell 153, 348-61. PMID: 23582325 5. Coll, RC. et al. (2015) Nature medicine 21, 248-55. PMID: 25686105 6. Song, H. et al. (2016) Nature communications 7, 13727. PMID: 27929086 7. Li, X. et al. (2017) Nature communications 8, 15986. PMID: 28656979 8. Nakanishi, H. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E7766-E7775. PMID: 28847925 9. Chen, J. et al. (2018) Nature 564, 71-76. PMID: 30487600 10. Mehto, S. et al. (2019) Molecular cell 73, 429-445.e7. PMID: 30612879 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human NLRP3 Antibody (18#)
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