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| 카탈로그 번호 | HA194013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1899 | ||||
| 타겟 | Protein FOAP-11, C15orf48, NMES1, Normal mucosa of esophagus-specific gene 1 protein | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q9C002 | ||||
| RRID | Anti-Human NMES1 Antibody (SAA1899) (abinScience Cat# HA194013, RRID:AB_3727663) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Cytochrome c oxidase associated subunit FA4L3 (NMES1) is a ~9 kDa protein. Mitochondrial small peptide that orchestrates a two-pronged immunoregulatory mechanism in response to inflammatory stimuli. Replaces the canonical cytochrome c oxidase subunit COXFA4 in mitochondrial complex IV and targets it to degradation, attenuating mitochondrial respiration, reducing membrane potential as well as ROS generation and modulates innate immune signaling. Additionally, initiates stress-independent autophagy by lowering ATP levels, activating AMPK-ULK1 signaling, boosting glutathione production, and thereby mitigating oxidative stress and supporting immune tolerance. 1. Lee, CQE. et al. (2021) Nature communications 12, 2130. PMID: 33837217 2. Clayton, SA. et al. (2021) Science advances 7, eabl5182. PMID: 34878835 3. Takakura, Y. et al. (2024) Nature communications 15, 953. PMID: 38296961 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human NMES1 Antibody (SAA1899)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
