Anti-Human NPC1L1 Polyclonal Antibody (HP159014)

Name: Anti-Human NPC1L1 Polyclonal Antibody
Brand: abinScience
SKU: HP159014
Price: 96 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HP159014

설명

Anti-Human NPC1L1 Polyclonal Antibody (HP159014) is a rabbit polyclonal antibody detecting NPC1L1 in ELISA, IHC, WB. Suitable for Rattus norvegicus and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human NPC1L1 (Arg450-Ser620).

타겟

NPC1L1

정제

Purified by antigen affinity column.

등록번호

Q9UHC9

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

NPC1-like intracellular cholesterol transporter 1, NPC1L1, Niemann-Pick C1-like protein 1, NPC1L1

배경

NPC1-like intracellular cholesterol transporter 1 (NPC1L1) is a ~148 kDa protein. Plays a major role in cholesterol homeostasis. Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation.

1. Yamanashi, Y. et al. (2012) Hepatology (Baltimore, Md.) 55, 953-64. PMID: 22095670

2. Garcia-Calvo, M. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8132-7. PMID: 15928087

3. Davies, JP. et al. (2005) The Journal of biological chemistry 280, 12710-20. PMID: 15671032

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human NPC1L1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human NPC1L1 Polyclonal Antibody (HP159014)

개요

이미지

참고 문헌

데이터시트

SDS