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| 카탈로그 번호 | HX127014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NPC2 (Asp31-Leu151). | ||||||||
| 타겟 | HE1, NPC intracellular cholesterol transporter 2, He1, Epididymal secretory protein E1, Human epididymis-specific protein 1, NPC2, Niemann-Pick disease type C2 protein | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P61916 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | NPC intracellular cholesterol transporter 2 (NPC2) is a ~16 kDa protein. Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. 1. Naureckiene, S. et al. (2000) Science (New York, N.Y.) 290, 2298-301. PMID: 11125141 2. Chikh, K. et al. (2005) Human mutation 26, 20-8. PMID: 15937921 3. Liou, HL. et al. (2006) The Journal of biological chemistry 281, 36710-23. PMID: 17018531 4. Infante, RE. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15287-92. PMID: 18772377 5. Berzina, Z. et al. (2018) Chemistry and physics of lipids 213, 48-61. PMID: 29580834 6. Gong, X. et al. (2016) Cell 165, 1467-1478. PMID: 27238017 7. Xu, Z. et al. (2008) Biochemistry 47, 11134-43. PMID: 18823126 | ||||||||
| 참고사항 | For research use only. |
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