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| 카탈로그 번호 | HF918014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NPHP4 (His1171-Gln1426). | ||||||||
| 타겟 | KIAA0673, Nephrocystin-4, NPHP4, Nephroretinin | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O75161 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Nephrocystin-4 (NPHP4) is a ~157 kDa protein. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1. 1. Delous, M. et al. (2009) Human molecular genetics 18, 4711-23. PMID: 19755384 2. Sang, L. et al. (2011) Cell 145, 513-28. PMID: 21565611 3. Burcklé, C. et al. (2011) Human molecular genetics 20, 2611-27. PMID: 21498478 4. Borgal, L. et al. (2012) The Journal of biological chemistry 287, 25370-80. PMID: 22654112 5. Habbig, S. et al. (2011) The Journal of cell biology 193, 633-42. PMID: 21555462 | ||||||||
| 참고사항 | For research use only. |
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