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| 카탈로그 번호 | HS713014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human NR0B2 Polyclonal Antibody (HS713014) is a rabbit polyclonal antibody detecting NR0B2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NR0B2 (Met1-Arg257). | ||||||||
| 타겟 | NR0B2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q15466 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 대체 이름 | Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner, NR0B2, SHP | ||||||||
| 배경 | Nuclear receptor subfamily 0 group B member 2 (NR0B2) is a ~28 kDa protein. Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism. Regulates the circadian expression of cytochrome P450 (CYP) enzymes. 1. Musille, PM. et al. (2012) Nature structural & molecular biology 19, 532-S2. PMID: 22504882 2. Kim, JY. et al. (2004) Molecular endocrinology (Baltimore, Md.) 18, 776-90. PMID: 14752053 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-NR0B2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse liver lysate
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