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| 카탈로그 번호 | HB802014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human NR1D1 Polyclonal Antibody (HB802014) is a rabbit polyclonal antibody detecting NR1D1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NR1D1 (Thr431-Gln614). | ||||||||
| 타겟 | THRAL, EAR1, EAR-1, NR1D1, Rev-erbA-alpha, Nuclear receptor subfamily 1 group D member 1, HREV, V-erbA-related protein 1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P20393 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Nuclear receptor subfamily 1 group D member 1 (NR1D1) is a ~66 kDa protein. Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-NR1D1 polyclonal antibody at 1µg/ml on various samples.
Lane 1: Mouse skeletal muscle lysate
Lane 2: Rat lung lysate
Lane 3: Rat liver lysate
Lane 4: Rat skeletal muscle lysate
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