Anti-Human NUPR1 Polyclonal Antibody (HA758014)

Name: Anti-Human NUPR1 Polyclonal Antibody
Brand: abinScience
SKU: HA758014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HA758014

설명

Anti-Human NUPR1 Polyclonal Antibody (HA758014) is a rabbit polyclonal antibody detecting Nuclear protein 1; Candidate of metastasis 1; Protein p8; NUPR1; COM1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human NUPR1 (Ala2-Arg82).

타겟

Nuclear protein 1; Candidate of metastasis 1; Protein p8; NUPR1; COM1

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O60356

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Nuclear protein 1 (NUPR1) is a ~8 kDa protein. Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses. Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A. Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation. Negatively regulates apoptosis through interaction with PTMA.

1. Encinar, JA. et al. (2001) The Journal of biological chemistry 276, 2742-51. PMID: 11056169

2. Hoffmeister, A. et al. (2002) The Journal of biological chemistry 277, 22314-9. PMID: 11940591

3. Malicet, C. et al. (2006) Biochemical and biophysical research communications 339, 284-9. PMID: 16300740

4. Malicet, C. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2671-6. PMID: 16478804

5. Clark, DW. et al. (2008) Current cancer drug targets 8, 421-30. PMID: 18690848

6. Gironella, M. et al. (2009) Journal of cellular physiology 221, 594-602. PMID: 19650074

7. Sambasivan, R. et al. (2009) Journal of cell science 122, 3481-91. PMID: 19723804

8. Kong, DK. et al. (2010) Molecular biology of the cell 21, 1335-49. PMID: 20181828

9. Hamidi, T. et al. (2012) The Journal of clinical investigation 122, 2092-103. PMID: 22565310

10. Vincent, AJ. et al. (2012) FEBS letters 586, 3429-34. PMID: 22858377

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human NUPR1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human NUPR1 Polyclonal Antibody (HA758014)

개요

이미지

참고 문헌

데이터시트

SDS