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| 카탈로그 번호 | HA252014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human OTUD1 Polyclonal Antibody (HA252014) is a rabbit polyclonal antibody detecting OTUD1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human OTUD1 (Met1-Ser481). | ||||||||
| 타겟 | DUBA7, DUBA-7, OTUD1, OTU domain-containing protein 1, OTDC1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q5VV17 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | OTU domain-containing protein 1 (OTUD1) is a ~51 kDa protein. Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation. 1. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 2. Snaurova, R. et al. (2022) Molecular and cellular biology 42, e0026522. PMID: 36445135 | ||||||||
| 참고사항 | For research use only. |
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