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| 카탈로그 번호 | HV433013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1724 | ||||
| 타겟 | PADI4, Peptidylarginine deiminase IV, HL-60 PAD, PADI5, Protein-arginine deiminase type-4, Protein-arginine deiminase type IV, PDI5, PAD4 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q9UM07 | ||||
| RRID | Anti-Human PADI4 Antibody (SAA1724) (abinScience Cat# HV433013, RRID:AB_3727485) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Protein-arginine deiminase type-4 (PADI4) is a ~74 kDa protein. Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. 1. Cuthbert, GL. et al. (2004) Cell 118, 545-53. PMID: 15339660 2. Wang, Y. et al. (2004) Science (New York, N.Y.) 306, 279-83. PMID: 15345777 3. Arita, K. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 5291-6. PMID: 16567635 4. Horikoshi, N. et al. (2011) Acta crystallographica. Section D, Biological crystallography 67, 112-8. PMID: 21245532 6. Lee, YH. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 3611-6. PMID: 15731352 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human PADI4 Antibody (SAA1724)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
