Anti-Human PCSK9 Recombinant Antibody (SAA0159), PE (HV275227)

Name: Anti-Human PCSK9 Recombinant Antibody (SAA0159), PE
Brand: abinScience
SKU: HV275227
Price: 290 USD
Availability: InStock

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개요
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참고 문헌
데이터시트
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개요

카탈로그 번호	HV275227
종 반응성	Human
응용 분야	FCM
숙주 종	Human
클론성	Monoclonal
이소타입	IgG4, kappa
클론 ID	SAA0159
접합	PE
타겟	EC:3.4.21.-, NARC-1, NARC1, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
관련 제품	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), PE
등록번호	Q8NBP7
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a ~74 kDa protein. Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. PCSK9 is the therapeutic target of evolocumab (Repatha). _x000D_ _x000D_ 1. Poirier, S. et al. (2008) The Journal of biological chemistry 283, 2363-72. PMID: 18039658 _x000D_ _x000D_ 2. Nassoury, N. et al. (2007) Traffic (Copenhagen, Denmark) 8, 718-32. PMID: 17461796 _x000D_ _x000D_ 3. Fan, D. et al. (2008) Biochemistry 47, 1631-9. PMID: 18197702 _x000D_ _x000D_ 4. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458 _x000D_ _x000D_ 5. Chen, Y. et al. (2011) Biochemical and biophysical research communications 415, 515-8. PMID: 22074827 _x000D_ _x000D_ 6. Jonas, MC. et al. (2008) EMBO reports 9, 916-22. PMID: 18660751
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.