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| 카탈로그 번호 | HW731014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PEX5 (His306-Gln639). | ||||||||
| 타겟 | Peroxisomal targeting signal 1 receptor, PTS1 receptor, PTS1-BP, PTS1R, Peroxin-5, Peroxisome receptor 1, PXR1, PEX5, Peroxisomal C-terminal targeting signal import receptor | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P50542 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Peroxisomal targeting signal 1 receptor (PEX5/PTS1) is a ~70 kDa protein. Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle. 1. Gatto, GJ. et al. (2000) Nature structural biology 7, 1091-5. PMID: 11101887 2. Dammai, V. et al. (2001) Cell 105, 187-96. PMID: 11336669 3. Harper, CC. et al. (2003) The Journal of biological chemistry 278, 7897-901. PMID: 12456682 4. Miyata, N. et al. (2005) Molecular and cellular biology 25, 10822-32. PMID: 16314507 5. Stanley, WA. et al. (2006) Molecular cell 24, 653-663. PMID: 17157249 6. Stanley, WA. et al. (2007) BMC structural biology 7, 24. PMID: 17428317 7. Freitas, MO. et al. (2011) The Journal of biological chemistry 286, 40509-19. PMID: 21976670 8. Zhang, J. et al. (2015) Nature cell biology 17, 1259-1269. PMID: 26344566 9. Fransen, M. et al. (1995) The Journal of biological chemistry 270, 7731-6. PMID: 7706321 10. Dodt, G. et al. (1995) Nature genetics 9, 115-25. PMID: 7719337 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-PEX5 polyclonal antibody at 1μg/ml on various samples.
Lane 1: 293T cell lysate
Lane 2: Mouse brain lysate
Lane 3: Rat brain lysate
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