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| 카탈로그 번호 | HF828014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human PHF14 Polyclonal Antibody (HF828014) is a rabbit polyclonal antibody detecting PHF14 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PHF14 (Ser296-Arg555). | ||||||||
| 타겟 | PHD finger protein 14, KIAA0783, PHF14 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O94880 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | PHD finger protein 14 (PHF14) is a ~106 kDa protein. Histone-binding protein. Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation. Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells. 1. Huang, Q. et al. (2013) Acta biochimica et biophysica Sinica 45, 622-33. PMID: 23688586 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-PHF14 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Rat brain lysate
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