Anti-Human PIN1 Polyclonal Antibody (HC505014)

Name: Anti-Human PIN1 Polyclonal Antibody
Brand: abinScience
SKU: HC505014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HC505014

설명

Anti-Human PIN1 Polyclonal Antibody (HC505014) is a rabbit polyclonal antibody detecting PIN1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PIN1 (Glu51-Glu163).

타겟

Rotamase Pin1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, PIN1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

정제

Purified by antigen affinity column.

등록번호

Q13526

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is a ~18 kDa protein. Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK.

1. Lee, TH. et al. (2011) Molecular cell 42, 147-59. PMID: 21497122

2. Steger, M. et al. (2013) Molecular cell 50, 333-43. PMID: 23623683

3. Nechama, M. et al. (2018) Nature communications 9, 1603. PMID: 29686383

4. Lim, JH. et al. (2011) The Journal of biological chemistry 286, 44403-11. PMID: 22033920

5. Yu, L. et al. (2006) The Journal of biological chemistry 281, 18201-7. PMID: 16644721

6. Dougherty, MK. et al. (2005) Molecular cell 17, 215-24. PMID: 15664191

7. Phan, RT. et al. (2007) Nature immunology 8, 1132-9. PMID: 17828269

8. Min, SH. et al. (2012) Molecular cell 46, 771-83. PMID: 22608923

10. Li, X. et al. (2016) Molecular cell 61, 705-719. PMID: 26942675

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human PIN1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human PIN1 Polyclonal Antibody (HC505014)

개요

이미지

참고 문헌

데이터시트

SDS