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| 카탈로그 번호 | HP333014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PIP5K1A (Lys62-Lys452). | ||||||||
| 타겟 | PIP5K1-alpha, PtdIns(4)P-5-kinase 1 alpha, Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha, PIP5KIalpha, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha, PIP5K1A, Phosphatidylinositol 4-phosphate 5-kinase type I alpha | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q99755 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) is a ~62 kDa protein. Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis. Can also use phosphatidylinositol (PtdIns) as substrate in vitro. Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps. 1. Shulga, YV. et al. (2011) Journal of molecular biology 409, 101-12. PMID: 21477596 2. Shulga, YV. et al. (2012) The Journal of biological chemistry 287, 35953-63. PMID: 22942276 3. Loijens, JC. et al. (1996) The Journal of biological chemistry 271, 32937-43. PMID: 8955136 4. Xie, Z. et al. (2009) Molecular biology of the cell 20, 1695-704. PMID: 19158393 5. Chao, WT. et al. (2010) The Journal of cell biology 190, 247-62. PMID: 20660631 6. Mellman, DL. et al. (2008) Nature 451, 1013-7. PMID: 18288197 | ||||||||
| 참고사항 | For research use only. |
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