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| 카탈로그 번호 | HS740014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human PLEKHO1 Polyclonal Antibody (HS740014) is a rabbit polyclonal antibody detecting PLEKHO1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PLEKHO1 (Glu23-Thr143). | ||||||||
| 타겟 | PH domain-containing family O member 1, CK2-interacting protein 1, Osteoclast maturation-associated gene 120 protein, OC120, JBP, Casein kinase 2-interacting protein 1, C-Jun-binding protein, CKIP1, PLEKHO1, CKIP-1, Pleckstrin homology domain-containing family O member 1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q53GL0 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Pleckstrin homology domain-containing family O member 1 (PLEKHO1) is a ~46 kDa protein. Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. | ||||||||
| 참고사항 | For research use only. |
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