Anti-Human PPARGC1A Polyclonal Antibody (HP446014)

Name: Anti-Human PPARGC1A Polyclonal Antibody
Brand: abinScience
SKU: HP446014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HP446014

설명

Anti-Human PPARGC1A Polyclonal Antibody (HP446014) is a rabbit polyclonal antibody detecting PPARGC1A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PPARGC1A (Ser636-Arg798).

타겟

LEM6, PGC1A, PPARGC1, Ligand effect modulator 6, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPARGC-1-alpha, PPARGC1A, PGC1

정제

Purified by antigen affinity column.

등록번호

Q9UBK2

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a ~91 kDa protein. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program.

1. Knutti, D. et al. (2000) Molecular and cellular biology 20, 2411-22. PMID: 10713165

2. Dominy, JE. et al. (2010) Biochimica et biophysica acta 1804, 1676-83. PMID: 20005308

3. Shin, JH. et al. (2011) Cell 144, 689-702. PMID: 21376232

4. Mays, SG. et al. (2017) Molecular pharmacology 92, 1-11. PMID: 28363985

5. Seacrist, CD. et al. (2020) Structure (London, England : 1993) 28, 830-846.e9. PMID: 32433991

8. Cho, Y. et al. (2013) The Journal of biological chemistry 288, 25207-25218. PMID: 23836911

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human PPARGC1A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human PPARGC1A Polyclonal Antibody (HP446014)

개요

이미지

참고 문헌

데이터시트

SDS

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